Comparing Trulicity vs Ozempic

James Wong • NiHowdy Founder
Reviewed October 1, 2023 • 26 min read

Are you seeking an effective weight loss solution while managing your type 2 diabetes? The battle to find the ideal medication can be daunting, but in the “trulicity vs ozempic” debate, both have emerged as promising contenders in this arena. In this comprehensive guide, we will delve into these two FDA-approved GLP-1 agonist medications, comparing their mechanisms of action, similarities, differences, and more, ultimately helping you make an informed decision for your health.

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✨ Short Summary

  • Trulicity and Ozempic are prescription medications used to treat type 2 diabetes, with similar benefits such as weight loss and cardiovascular health.
  • Differences between the two include effectiveness in weight loss, safety concerns, patient preferences, dosage recommendations & injection techniques.
  • Switching between Trulicity and Ozempic should be done under medical supervision for proper dosing & monitoring.

Understanding Ozempic and Trulicity

Trulicity and Ozempic are FDA-approved GLP-1 agonist medications primarily designed to treat type 2 diabetes. They work by improving blood sugar control and reducing the risk of cardiovascular events in adults with this condition.

Although both these drugs share similar mechanisms of action and benefits for weight loss and cardiovascular health, they have different active ingredients and are not available in biosimilar forms.

What is Trulicity?

Trulicity is a once-weekly injectable medication that contains the active ingredient dulaglutide, helping manage blood sugar levels and reduce the risk of cardiovascular events in adults and children with Type 2 diabetes. Despite not being primarily indicated for weight loss, Trulicity has been found to help patients lose weight in certain circumstances, as demonstrated in a randomized clinical trial published in 2021.

Patients taking Trulicity may come across mild side effects. These include nausea, diarrhea, vomiting, abdominal pain, and reduced appetite.

What is Ozempic?

On the other hand, Ozempic is also a once-weekly injectable medication, but it contains the active ingredient semaglutide. It is designed to improve blood sugar control and reduce the risk of major cardiovascular events in adults with Type 2 diabetes.

Similar to Trulicity, Ozempic has been found to aid in weight loss and blood sugar management.

Comparing the Mechanisms of Action

Trulicity and Ozempic both function by stimulating insulin release in response to high blood sugar levels, reducing sugar production in the liver, and slowing down digestion. These mechanisms of action help control blood sugar levels and promote weight loss, in accordance with the American Diabetes Association’s recommendations for managing type 2 diabetes.

By stimulating insulin release, reducing sugar production, and slowing down digestion, Trulicity works.

Insulin Stimulation

When it comes to insulin stimulation, both Trulicity and Ozempic act by stimulating the secretion of insulin from the pancreas in the presence of elevated blood glucose levels. This assists in the regulation of blood glucose levels and in mitigating the potential complications associated with diabetes.

By stimulating the secretion of insulin, these medications can help reduce the risk of long-term damage.

Blood Sugar Production Reduction

By reducing sugar production in the liver, Trulicity and Ozempic help maintain blood sugar levels and prevent hyperglycemia, a major concern for individuals with type 2 diabetes, thus contributing to better glycemic control.

Hyperglycemia, which is the opposite of low blood sugar, can lead to serious health complications, including multiple cardiovascular risk factors, such as heart disease, stroke, and kidney issues. For more information and guidance, consult the American Diabetes Association.

Slowing Digestion

Slowing down digestion is another shared mechanism of action for Trulicity and Ozempic. This effect helps with weight loss and blood sugar control by reducing caloric and carbohydrate intake, ultimately leading to improved weight control and blood sugar levels.

By slowing down digestion, Trulicity and Ozempic can help people achieve their weight.

Similarities Between Trulicity and Ozempic

Trulicity and Ozempic share several similarities, including their once-weekly injection schedule, side effects such as nausea, diarrhea, and constipation, and benefits for weight loss and cardiovascular health. These similarities make both medications viable options for patients seeking to manage their type 2 diabetes while also targeting weight loss.

Both medications offer a convenient injection schedule, with Trulicity requiring a once-weekly injection.

Weekly Injections

One notable similarity between Trulicity and Ozempic is their convenient once-weekly injection schedule. This dosing frequency makes it easier for patients to remember and administer their medication, ultimately improving adherence to their treatment plan.

Adherence to treatment plans is an important factor in achieving positive health outcomes. Studies have shown that clinical trials play a crucial role in determining the effectiveness of these treatment plans.

Side Effects

Both Trulicity and Ozempic have similar side effects, ranging from mild gastrointestinal issues like nausea, vomiting, diarrhea, and abdominal pain to more serious concerns like thyroid cancer, as indicated by their boxed warning.

However, the severity and frequency of these major adverse cardiovascular events may differ between patients due to various risk factors, and a healthcare provider should be consulted to discuss potential risks and benefits.

Differences Between Trulicity and Ozempic

Despite their similarities, Trulicity and Ozempic also have some differences, particularly in terms of their effectiveness in weight loss, safety concerns, and patient preferences. Understanding these differences can help patients and healthcare providers decide which medication, Ozempic or Trulicity, is best suited for their individual needs.

Weight loss is one of the primary goals of diabetes treatment, and both Trulicity and Diabetes.

Effectiveness in Weight Loss

In terms of weight loss, some studies suggest that Ozempic may be more effective at promoting weight loss than Trulicity. However, individual results may vary, and it is essential to consult with a healthcare provider to determine the most appropriate medication for each patient’s specific situation.

It is important to remember that weight loss medications are not a substitute for healthy lifestyle changes. Eating a balanced diet and maintaining an appropriate body weight are crucial factors in achieving long-term success, especially when dealing with a decreased appetite.

Safety Concerns

Although both medications have safety concerns, including a boxed warning for thyroid cancer risk, the severity and frequency of side effects may differ between patients. Therefore, it is crucial for patients to discuss any safety concerns with their healthcare provider before starting or switching between these medications.

Making an informed decision about which medication to take is important for patient safety and satisfaction, and understanding the drug class can be helpful in this process.

Patient Preferences

Patient preferences may also play a role in choosing between Trulicity and Ozempic, as some individuals may respond better to one medication over the other. Factors such as route of administration, injection device, and personal experience with the medications can influence patient preferences.

As always, it is important to consult with a healthcare professional for personalized recommendations.

Dosage and Administration

Trulicity and Ozempic have specific dosage and administration guidelines, including starting doses, dose adjustments, and injection techniques. Adhering to these guidelines is essential for optimal blood sugar control and weight management.

It is important to follow the instructions provided by your healthcare provider when taking Trulicity or Ozempic.

Starting Doses

Both medications have relatively low starting doses, which can be gradually increased based on patient response and tolerance. The recommended starting dose for Trulicity is 0.75 mg once weekly, while the initial dose for Ozempic is 0.25 mg weekly for the first four weeks.

Dose Adjustments

Dose adjustments may be necessary for patients experiencing side effects or not achieving desired blood sugar control. Trulicity doses can be increased incrementally up to a maximum of 4.5 mg weekly, while Ozempic doses can be increased up to a maximum of 2 mg weekly.

It is important to consult with a healthcare provider before making any dose adjustments.

Injection Techniques

Both Trulicity and Ozempic are administered via subcutaneous injection, with specific techniques for each medication. Trulicity can be injected in the abdomen, thigh, or upper arm, with a rotation of injection sites recommended for each dose.

Ozempic, on the other hand, is administered subcutaneously once a week in the upper arm, upper thigh, or abdomen.

Cost Comparison: Trulicity vs Ozempic

Trulicity and Ozempic are both expensive medications, but cost differences, insurance coverage, and copay assistance programs may influence patient choice. As of March 2023, the list price of Trulicity is $930.88 per month, while the list price of Ozempic is $892.06 per 28-day supply.

Various cost-saving options are available for both medications. Manufacturer copay savings cards can significantly reduce the cost of certain medications for eligible patients with commercial insurance. This cost can be reduced to as little as $25. Additionally, patient assistance programs may provide the medication at no cost for those without insurance coverage or with limited coverage.

It is important to discuss these options with a healthcare provider to determine the best course of action based on individual financial circumstances.

Switching Between Trulicity and Ozempic

Switching between Trulicity and Ozempic is possible, but should be done under the guidance of a healthcare provider to ensure proper dosing and monitoring. Although both medications have similar indications and benefits for weight loss and cardiovascular health, their different active ingredients and specific uses may influence the decision to switch.

Before making any changes to your medication regimen, it is essential to consult with your healthcare provider. They can provide insight as to whether transitioning from Trulicity to Ozempic or vice versa is a viable option, and help guide you through the process of switching medications while monitoring your blood sugar levels and overall health.

Off-Label Use for Weight Loss

Although not FDA-approved for weight loss, Trulicity and Ozempic may be prescribed off-label for this purpose due to their appetite-reducing effects and potential for weight loss in some patients. Off-label use refers to the prescription of a drug for a purpose other than what it has been approved for by the FDA.

While off-label use of Trulicity and Ozempic for weight loss may provide some benefits, it is important to discuss the potential risks and benefits with your healthcare provider before initiating any off-label use. Potential side effects such as nausea, vomiting, and diarrhea should be considered, as well as the individual’s overall health and medical history.


In conclusion, Trulicity and Ozempic are both FDA-approved GLP-1 agonist medications that offer benefits for managing type 2 diabetes and promoting weight loss. With their similar mechanisms of action, weekly injection schedules, and potential side effects, they provide viable options for individuals seeking a comprehensive treatment plan. However, differences in effectiveness, safety concerns, and patient preferences should be considered when choosing between these medications. As always, consulting with a healthcare professional is essential for making an informed decision and ensuring optimal blood sugar control and weight management.

Frequently Asked Questions

Which is better, Ozempic or Trulicity?

Ozempic (semaglutide) seems to have a slight edge over Trulicity, with research suggesting it provides more effective weight reduction and lower A1C levels than Trulicity.

However, there may be less gastrointestinal side effects with Trulicity and other GLP-1 medications.

How is Trulicity different from Ozempic?

Trulicity and Ozempic are both GLP-1 medications used to treat type 2 diabetes, but they differ in their active ingredients; Trulicity contains dulaglutide, while Ozempic contains semaglutide.

Can you switch from Ozempic to Trulicity for weight loss?

It is possible to switch from Ozempic to Trulicity for weight loss, as they belong to the same GLP-1 family and are both injected once per week.

However, it is advisable to consult a doctor before making any changes to your drug regimen.

What are the main benefits of Trulicity and Ozempic for individuals with type 2 diabetes?

Trulicity and Ozempic offer significant benefits for individuals with type 2 diabetes, including improved blood sugar levels, reduced risk of cardiovascular events, and potential weight loss benefits.

Can Trulicity and Ozempic be prescribed off-label for weight loss?

Trulicity and Ozempic may be prescribed off-label for weight loss due to their appetite-reducing effects, though it is important to discuss potential risks and benefits with a healthcare provider before starting. It is important to consider the potential risks and benefits of any medication before starting, and to discuss these with a healthcare provider.

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